Caught in a terrible snowstorm on his way back to New York, the famous writer Paul Sheldon crashes into a ravine with his car. Seriously injured, he is saved by a strange nurse, Annie Wilkes who brings him back to her house isolated from everything. She is a fan of Misery, the heroine of Paul Sheldon's novels, with whom she has totally identified. She will discover the writer's new manuscript ... and the horror begins for him. Her only chance of survival: writing, writing, writing, for the monstrous, for the insatiable Annie ...